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Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin 期刊论文

编号：

f9f4f288-8a56-412b-824f-da0ab6703096
作者：

Song, Jin^[1];Ge, Zhouhong^[1];Yang, Xinrong(杨欣荣)^[2,3]Luo, Qin^[1];Wang, Cun^[1];You, Haiyan^[1];Ge, Tianxiang^[1];Deng, Yun^[1];Lin, Hechun^[1];Cui, Yongqi^[1];Chu, Wei^[1];Yao, Ming^[1];Zhang, Zhigang^[1];Gu, Jianren^[1];Fan, Jia(樊嘉)*^[2,3]Qin, Wenxin^[1];
语种：

English
期刊：

CANCER LETTERS ISSN：0304-3835 2015 年 356 卷 2 期 (713 - 720) ; JAN 28
收录：
关键词：

Acidic tumor microenvironment Hepatic stellate cells Proton pump inhibitor Glycolysis
摘要：

Extracellular pH of solid tumor is generally acidic due to excessive glycolysis and poor perfusion. But whether acidic tumor microenvironment influenced the stromal cells infiltrating in tumor remains unknown. As the predominant progenitor of stromal cells in liver, the number of activated hepatic stellate cells (HSCs) was found positively correlated to the acidification level in the tumor tissues of HCC patients in our study. Whereas, in vitro acidic culture condition and in vivo co-implanting xenograft model were adopted to study the response of HSCs and its influence on HCC progression. HSCs were activated under acidic culture condition depending on the phosphorylation of cellular signal-regulated kinase (ERK). Acidity-activated HSCs promoted HCC metastasis in vitro and in vivo. Osteopontin (OPN) excretion from HSCs was increased under acidic condition and proved to promote the migration of HCC cells. Furthermore, the expression level of OPN was significantly associated with myofibroblasts and the combination of alpha-SMA with OPN was a powerful predictor for poor prognosis of HCC patients. Activation of HSCs in acidic tumor microenvironment represents a novel mechanism for HCC metastasis and provides a potential therapeutic strategy for HCC. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Song Jin,Ge Zhouhong,Yang Xinrong, et al. Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin [J].CANCER LETTERS,2015,356(2):713-720.
APA：

Song Jin,Ge Zhouhong,Yang Xinrong,Luo Qin,&Qin Wenxin.(2015).Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin .CANCER LETTERS,356(2):713-720.
MLA：

Song Jin, et al. "Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin" .CANCER LETTERS 356,2(2015):713-720.

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