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Local recurrence following mastectomy and autologous breast reconstruction: incidence, risk factors, and management 期刊论文

编号：

fdb10fa1-8227-421f-961f-092044f88296
作者：

Wu, Siyu^[1,2];Mo, Miao^[3];Wang, Yujie^[1,2];Zhang, Na^[1,2];Li, Jianwei(李剑伟)^[1,2]Di, Genhong(狄根红)^[1,2]Shao, Zhimin(邵志敏)^[1,2]Wu, Jiong^[1,2];Liu, Guangyu(柳光宇)*^[1,2]
语种：

English
期刊：

ONCOTARGETS AND THERAPY ISSN：1178-6930 2016 年 9 卷 (6829 - 6834)
收录：
关键词：

local recurrence autologous breast reconstruction incidence risk factors management
摘要：

Background: Breast reconstruction (BR), including autologous breast reconstruction (ABR) after mastectomy (MST), has been gaining popularity all around the world, especially in the People's Republic of China during the past decade. However, there is a small proportion, but a significant number, of patients who develop local recurrence (LR) of breast cancer post-operatively. The purpose of this study is to examine the incidence of LR, discuss risk factors associated with LR, and management of LR following MST and ABR. Methods: A total of 397 patients who underwent MST and ABR after diagnosis of breast cancer were included in this retrospective study. Data were analyzed by the Kaplan-Meier method, the log-rank statistical test, and Cox proportional hazards model. Results: From January 1999 to December 2011, 400 ABRs were performed in 397 patients in Fudan University Shanghai Cancer Center. The median follow-up time in the study was 3.6 years. LR occurred in 11 of 397 patients, with a median time to LR of 2.9 years. In univariate and multivariate analyses, tumor stage, hormonal therapy (yes or no), and tumor type (multifocal or nonmultifocal) were significantly associated with LR after ABR following MST. Conclusion: ABR is an oncologically safe surgical procedure with an acceptable LR rate of 2.8%. Risk factors associated with high rate of LR were higher tumor stage, absence of hormonal therapy, and multifocal tumor type.
推荐引用方式
GB/T 7714：

Wu Siyu,Mo Miao,Wang Yujie, et al. Local recurrence following mastectomy and autologous breast reconstruction: incidence, risk factors, and management [J].ONCOTARGETS AND THERAPY,2016,9:6829-6834.
APA：

Wu Siyu,Mo Miao,Wang Yujie,Zhang Na,&Liu Guangyu.(2016).Local recurrence following mastectomy and autologous breast reconstruction: incidence, risk factors, and management .ONCOTARGETS AND THERAPY,9:6829-6834.
MLA：

Wu Siyu, et al. "Local recurrence following mastectomy and autologous breast reconstruction: incidence, risk factors, and management" .ONCOTARGETS AND THERAPY 9(2016):6829-6834.

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