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Novel lymph node ratio predicts prognosis of colorectal cancer patients after radical surgery when tumor deposits are counted as positive lymph nodes: a retrospective multicenter study 期刊论文

编号：

ff289115-743c-4a5e-8898-164c2e48bd78
作者：

Yang, Jin^[1] Xing, Shasha^[1] Li, Jun^[2,3] Yang, Shengke^[4] Hu, Junjie^[5] Liu, Hao^[6] Du, Feng^[7,8] Yin, Jie^[9] Liu, Sai^[10] Li, Ci^[11] Yuan, Jiatian^[2] Lv, Bo^[2]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 45 期 (73865 - 73875) ; NOV 8
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关键词：

lymph node ratio tumor deposits colorectal cancer prognosis
摘要：

The lymph node ratio (LNR), defined as the relation of tumor-infiltrated to resected lymph nodes, has been identified as an independent prognostic factor for colorectal cancer (CRC) after radical surgery. Recently, new guidelines propose counting tumor deposits (TDs) as positive lymph nodes (pLNs). The aim of this study was to investigate whether a novel LNR (nLNR) that considers TDs as pLNs can be used to accurately predict the long-term outcome of CRC patients. In this multicenter retrospective study, clinicopathological and outcome data from 2,051 stage III CRC patients who underwent R0 resection were collected between January 2004 and December 2011. Disease-free survival (DFS) and overall survival (OS) according to the nLNR category were analyzed using Kaplan-Meier survival curves. Univariate and multivariate analyses were performed to determine significant prognostic factors, and ROC curves were computed to measure the predictive capacity of the nLNR category. The 5-year DFS rates of nLNR1-4 were 68.3%, 48.4%, 33.3% and 16.5%, respectively (P<0.0001), and the 5-year OS rate of nLNR1-4 were 71.8%, 60.1%, 42.7% and 21.8%, respectively (P<0.0001). The area of under curve (AUC) of the nLNR was 0.686 (95% CI 0.663-0.710) and 0.672 (95% CI 0.648-0.697) for predicting DFS and OS. Our results demonstrate that the nLNR predicted long-term outcomes better than the LNR, npN and pN, using the cutoff points 0.250, 0.500 and 0.750.
推荐引用方式
GB/T 7714：

Yang Jin,Xing Shasha,Li Jun, et al. Novel lymph node ratio predicts prognosis of colorectal cancer patients after radical surgery when tumor deposits are counted as positive lymph nodes: a retrospective multicenter study [J].ONCOTARGET,2016,7(45):73865-73875.
APA：

Yang Jin,Xing Shasha,Li Jun,Yang Shengke,&Lv Bo.(2016).Novel lymph node ratio predicts prognosis of colorectal cancer patients after radical surgery when tumor deposits are counted as positive lymph nodes: a retrospective multicenter study .ONCOTARGET,7(45):73865-73875.
MLA：

Yang Jin, et al. "Novel lymph node ratio predicts prognosis of colorectal cancer patients after radical surgery when tumor deposits are counted as positive lymph nodes: a retrospective multicenter study" .ONCOTARGET 7,45(2016):73865-73875.

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