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Cardiac Dose Control and Optimization Strategy for Left Breast Cancer Radiotherapy With Non-Uniform VMAT Technology 期刊论文

编号：

1CD08154DC9E98599198B34D5CE26C09
作者：

Qiu, Jianjian^[1] Zhang, Shujun^[1] Lv, Bo^[1] Zheng, Xiangpeng^[1]
语种：

英文
期刊：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT ISSN：1533-0346 2021 年 20 卷 ; NOV
收录：
关键词：

breast cancer cardiac dose non-uniform volumetric modulated arc therapy (NU-VMAT) intensity-modulated radiation therapy optimization
摘要：

Purpose: A novel in-house technology "Non-Uniform VMAT (NU-VMAT)" was developed for automated cardiac dose reduction and treatment planning optimization in the left breast radiotherapy. Methods: The NU-VMAT model based on I-GM (gantry MLC Movement coefficient index) was established to optimize the volumetric modulated arc therapy (VMAT) MLC movement and modulation intensity in certain gantry angles. The ESAPI embedded in Eclipse (R) was employed to connect TPS and the optimization program via I/O relevant DICOM RT files. The adjuvant whole-breast radiotherapy of 14 patients with left breast cancer was replanned using our NU-VMAT technology in comparison with VMAT and IMRT technology. Dosimetric parameters including D-1%, D-99%, and D-mean of PTV, V-5, V-10, and V-20 of ipisilateral lung, V-5, D-20, D-30, and D-mean of heart, monitor units (MUs), and delivery time derived from IMRT, VMAT, and NU-VMAT plans were evaluated for plan quality and delivery efficiency. The quality assurance (QA) was conducted using both point-dose and planar-dose measurements for all treatment plans. Results: The IGM-NU-VMAT curves with plan optimization (range from 50% to 147%) were converged more significantly than I-GM-(VMAT) curves (range from 0% to 297%). The dose distribution requirements of the target and normal tissues could be met using IMRT, VMAT, or NU-VMAT; the lowest D-mean was achieved in NU-VMAT plans (5.38 +/- 0.46 Gy vs 5.63 +/- 0.61 Gy in IMRT and 7.95 +/- 0.52 Gy in VMAT plans). Statistically significant differences were found in terms of delivery time and MU when comparing IMRT with VMAT and NU-VMAT plans (P < .05). In comparison with IMRT plans, the MU and delivery time in NU-VMAT plans dramatically decreased by 69.8% and 28.4%, respectively. Moreover, NU-VMAT plans showed a high gamma passing rate (96.5% +/- 1.11) in plane dose verification and minimal dose difference (2.4% +/- 0.19) in point absolute dose verification. Conclusion: Our non-uniform VMAT facilitated the treatment strategy optimization for left breast cancer radiotherapy with dosimetric advantage in cardiac dose reduction and delivery efficiency in comparison with the conventional VMAT and IMRT.
推荐引用方式
GB/T 7714：

Qiu Jianjian,Zhang Shujun,Lv Bo, et al. Cardiac Dose Control and Optimization Strategy for Left Breast Cancer Radiotherapy With Non-Uniform VMAT Technology [J].TECHNOLOGY IN CANCER RESEARCH & TREATMENT,2021,20.
APA：

Qiu Jianjian,Zhang Shujun,Lv Bo,Zheng Xiangpeng.(2021).Cardiac Dose Control and Optimization Strategy for Left Breast Cancer Radiotherapy With Non-Uniform VMAT Technology .TECHNOLOGY IN CANCER RESEARCH & TREATMENT,20.
MLA：

Qiu Jianjian, et al. "Cardiac Dose Control and Optimization Strategy for Left Breast Cancer Radiotherapy With Non-Uniform VMAT Technology" .TECHNOLOGY IN CANCER RESEARCH & TREATMENT 20(2021).
入库时间：

2023/12/2 0:00:00
更新时间：

2023/12/2 0:00:00

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