首页 / 院系成果 / 成果详情页

Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus 期刊论文

编号：

38265ECD6173A5DB93ED5FCBA320AD17
作者：

Lei, Ying^[3,5];Liang, Xian^[1,2,4];Sun, Yunong^[3,5];Yao, Ting(姚婷)^[6]Gong, Hongyu^[7];Chen, Zhenhua^[8];Gao, Yuanqing(高原青)^[9]Wang, Hui^[4];Wang, Ru^[10];Huang, Yunqi^[3];Yang, Tao^[11];Yu, Miao(于淼)^[4]Liu, Longqi(刘龙奇)^[3,5]Yi, ChunXia^[12]Wu, QingFeng(吴青峰)^[8]Kong, Xingxing^[4]Xu, Xun^[3,5];Liu, Shiping(刘仕平)^[3,5]Zhang, Zhi(张智)^[1,2,4]Liu, Tiemin(刘铁民)^[1,2,4,7]
语种：

英文
期刊：

CELL METABOLISM ISSN：1550-4131 2024 年 36 卷 2 期 ; FEB 6
收录：
摘要：

The hypothalamus plays a crucial role in the progression of obesity and diabetes; however, its structural complexity and cellular heterogeneity impede targeted treatments. Here, we profiled the single -cell and spatial transcriptome of the hypothalamus in obese and sporadic type 2 diabetic macaques, revealing primate -specific distributions of clusters and genes as well as spatial region, cell -type-, and gene -feature -specific changes. The infundibular (INF) and paraventricular nuclei (PVN) are most susceptible to metabolic disruption, with the PVN being more sensitive to diabetes. In the INF, obesity results in reduced synaptic plasticity and energy sensing capability, whereas diabetes involves molecular reprogramming associated with impaired tanycytic barriers, activated microglia, and neuronal inflammatory response. In the PVN, cellular metabolism and neural activity are suppressed in diabetic macaques. Spatial transcriptomic data reveal microglia''s preference for the parenchyma over the third ventricle in diabetes. Our findings provide a comprehensive view of molecular changes associated with obesity and diabetes.
推荐引用方式
GB/T 7714：

Lei Ying,Liang Xian,Sun Yunong, et al. Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus [J].CELL METABOLISM,2024,36(2).
APA：

Lei Ying,Liang Xian,Sun Yunong,Yao Ting,&Liu Tiemin.(2024).Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus .CELL METABOLISM,36(2).
MLA：

Lei Ying, et al. "Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus" .CELL METABOLISM 36,2(2024).
入库时间：

2025/2/19 11:43:52
更新时间：

2025/2/21 12:42:40

浏览次数：8  下载次数：0

分享到：

浏览次数：8

下载次数：0

打印次数：0