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HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis 期刊论文

编号：

42C540CBAD820105E12603BB8C459E5F
作者：

Zhong, Xinyang^[1,2];Wang, Yaxian^[1,2];He, Xuefeng^[3];He, Xinxin^[4];Hu, Zijuan^[2,5,6,7];Huang, Huixia^[2,5,6,7];Chen, Jiayu^[1,2];Chen, Keji^[2,5,6,7];Wei, Ping(危平)^[2,5,6,7]Zhao, Senlin(赵森林)^[1,2]Wang, Yilin(王益林)^[2,8]Zhang, Hong(张宏)^[9]Feng, Bo(冯波)^[10]Li, Dawei(李大卫)^[1,2]
语种：

英文
期刊：

CELL DEATH & DISEASE ISSN：2041-4889 2024 年 15 卷 9 期 ; SEP 3
收录：
摘要：

lncRNA can regulate tumorigenesis development and distant metastasis of colorectal cancer (CRC). However, the detailed molecular mechanisms are still largely unknown. Using RNA-sequencing data, RT-qPCR, and FISH assay, we found that HIF1A-AS2 was upregulated in CRC tissues and associated with poor prognosis. Functional experiments were performed to determine the roles of HIF1A-AS2 in tumor progression and we found that HIF1A-AS2 can promote the proliferation, metastasis, and aerobic glycolysis of CRC cells. Mechanistically, HIF1A-AS2 can promote FOXC1 expression by sponging miR-141-3p. SP1 can transcriptionally activate HIF1A-AS2. Further, HIF1A-AS2 can be packaged into exosomes and promote the malignant phenotype of recipient tumor cells. Taken together, we discovered that SP1-induced HIF1A-AS2 can promote the metabolic reprogramming and progression of CRC via miR-141-3p/FOXC1 axis. HIF1A-AS2 is a promising diagnostic marker and treatment target in CRC.
推荐引用方式
GB/T 7714：

Zhong Xinyang,Wang Yaxian,He Xuefeng, et al. HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis [J].CELL DEATH & DISEASE,2024,15(9).
APA：

Zhong Xinyang,Wang Yaxian,He Xuefeng,He Xinxin,&Li Dawei.(2024).HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis .CELL DEATH & DISEASE,15(9).
MLA：

Zhong Xinyang, et al. "HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis" .CELL DEATH & DISEASE 15,9(2024).
入库时间：

2025/2/19 14:32:24
更新时间：

2025/2/21 12:42:40

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