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Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice 期刊论文

编号：

88AE43B595338A85C34AA2CA8777FE9A
作者：

Hu, Qinfeng^[1];Chen, Hang^[2,3];Shen, Cheng^[4];Zhang, Beijian^[3,5,6];Weng, Xinyu^[3,5,6];Sun, Xiaolei(孙晓垒)^[3,5,6]Liu, Jin^[3,5,6];Dong, Zhen^[3,5,6];Hu, Kai(胡凯)^[1,3]Ge, Junbo(葛均波)^[1,3,5,6]Sun, Aijun(孙爱军)*^[1,3,5,6]
语种：

英文
期刊：

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH ISSN：2993-7175 2022 年 46 卷 5 期 (707 - 723) ; MAY
收录：
关键词：

aldehyde dehydrogenase 2 calcium handling CaMKII moderate alcohol reactive oxygen species
摘要：

Background Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism. The ALDH2*2 mutations are found in approximately 45% of East Asians, with 40% being heterozygous (HE) ALDH2*1/*2 and 5% homozygous (HO) ALDH2*2/*2. Studies have shown that HO mice lack cardioprotective effects induced by moderate alcohol consumption. However, the impact of moderate alcohol consumption on cardiac function in HE mice is unknown. Methods In this study, HO, HE, and wild-type (WT) mice were subjected to a 6-week moderate alcohol drinking protocol, following which myocardial tissue and cardiomyocytes of the mice were extracted. Results We found that moderate alcohol exposure did not increase mortality, myocardial fibrosis, apoptosis, or inflammation in HE mice, which differs from the effects observed in HO mice. After exposure to the 6-week alcohol drinking protocol, there was impaired cardiac function, cardiomyocyte contractility, and intracellular Ca2+ homeostasis and mitochondrial function in both HE and HO mice as compared to WT mice. Moreover, these animals showed overt oxidative stress production and increased levels of the activated forms of calmodulin-dependent protein kinase II (CaMKII) and ryanodine receptor type 2 (RYR2) phosphorylation protein. Conclusion We found that moderate alcohol exposure impaired cardiac function in HE mice, possibly by increasing reactive oxygen species (ROS)/CaMKII/RYR2-mediated Ca2+ handling abnormalities. Hence, we advocate that people with ALDH2*1/*2 genotypes rigorously avoid alcohol consumption to prevent potential cardiovascular harm induced by moderate alcohol consumption.
推荐引用方式
GB/T 7714：

Hu Qinfeng,Chen Hang,Shen Cheng, et al. Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice [J].ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH,2022,46(5):707-723.
APA：

Hu Qinfeng,Chen Hang,Shen Cheng,Zhang Beijian,&Sun Aijun.(2022).Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice .ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH,46(5):707-723.
MLA：

Hu Qinfeng, et al. "Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice" .ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH 46,5(2022):707-723.
入库时间：

2023/12/2 0:00:00
更新时间：

2023/12/2 0:00:00

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