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KM55 Monoclonal Antibody Staining in IgA-Dominant Infection-Related Glomerulonephritis 期刊论文

编号：

92966DC9FCE944EC0144125D36D7FBE1
作者：

Zhang, Minfang^[1];Zhou, Wenyan^[1];Liu, Shaojun(刘少军)*^[2]Zhang, Liyin^[2];Ni, Zhaohui^[1];Hao, Chuanming(郝传明)^[2]
语种：

英文
期刊：

NEPHRON ISSN：1660-8151 2021 年 145 卷 3 期 (225 - 237) ; MAY
收录：
关键词：

KM55 monoclonal antibody IgA-dominant infection-related glomerulonephritis IgA nephropathy
摘要：

Introduction: IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN), due to overlapping clinical and pathological features. The key factor in the pathogenesis of IgAN is galactose-deficient IgA1 (Gd-IgA1). However, the mechanism of glomerular IgA deposition in patients with IgA-IRGN is unclear. Therefore, we evaluated whether Gd-IgA1 could be a useful biomarker to distinguish between these 2 diseases. Methods: A case-control study was conducted to analyze the clinical and pathological characteristics of 12 patients with IgA-IRGN. The intensity and distribution of glomerular Gd-IgA1 (KM55) staining in renal biopsies were assessed. The control group consisted of 15 patients diagnosed with IgAN and an additional 17 patients with glomerulopathy involving IgA deposition. Results: The main clinical manifestations of patients with IgA-IRGN were nephrotic-range proteinuria, hematuria, acute renal injury, and hypocomplementemia. Active lesions were the leading pathological feature, while focal segmental sclerosis was rare. Half of the patients exhibited hump-shaped subepithelial deposits. Glomerular KM55 staining was negative in 7 patients, trace in 4 patients, and 2+ in 1 patient. The median intensity of KM55 staining in IgA-IRGN patients was 0 (range 0 similar to 2+), which was significantly lower than that of primary IgAN patients (median 2+, range 1+similar to 3+). The receiver operating characteristic analysis demonstrated that the optimal cutoff level to identify these 2 diseases was 0.5+. Conclusions: Glomerular KM55 staining intensity might be helpful to distinguish IgA-IRGN from primary IgAN. Weak or negative staining may favor IgA-IRGN. In addition, integrated analysis including clinical data, pathological findings, and prognostic information would further improve the differential diagnosis.
推荐引用方式
GB/T 7714：

Zhang Minfang,Zhou Wenyan,Liu Shaojun, et al. KM55 Monoclonal Antibody Staining in IgA-Dominant Infection-Related Glomerulonephritis [J].NEPHRON,2021,145(3):225-237.
APA：

Zhang Minfang,Zhou Wenyan,Liu Shaojun,Zhang Liyin,&Hao Chuanming.(2021).KM55 Monoclonal Antibody Staining in IgA-Dominant Infection-Related Glomerulonephritis .NEPHRON,145(3):225-237.
MLA：

Zhang Minfang, et al. "KM55 Monoclonal Antibody Staining in IgA-Dominant Infection-Related Glomerulonephritis" .NEPHRON 145,3(2021):225-237.
入库时间：

2023/12/2 0:00:00
更新时间：

2023/12/2 0:00:00

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