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MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth 期刊论文

编号：

DFA14A891E59C8E4C4A7530EBE74A51E
作者：

Fan, Kun^[1,2,3] Wang, Jiwen^[1,2,3] Sun, Wentao^[1,2,3] Shen, Sheng^[1,2,3] Ni, Xiaojian^[1,2,3] Gong, Zijun^[1,2,3] Zheng, Bohao^[1,2,3] Gao, Zhihui^[1,2,3] Ni, Xiaoling^[1,2,3] Suo, Tao^[1,2,3] Liu, Houbao^[1,2,3] Liu, Han^[1,2,3]
语种：

英文
期刊：

EXPERIMENTAL CELL RESEARCH ISSN：0014-4827 2020 年 394 卷 1 期 ; SEP 1
收录：
关键词：

MUC16c Glycolysis Gallbladder carcinoma ALDOC AMPK pathway
摘要：

The MUC16 C-terminal (MUC16c) level is associated with tumor serum CA-125 levels, however, the roles remain unclear in gallbladder carcinoma (GBC). In this study, we found that MUC16c promoted glucose uptake and glycolysis for GBC cell proliferation. Mass spectrometry analysis suggested that MUC16c could combine with aldolase. The ALDOC mRNA and protein are overexpressed in GBC tumors. The IHC results also showed the consistent up-regulation of. ALDOC and MUC16c level in GBC tumor tissues than in peritumor tissues. We determined that MUC16c combining with ALDOC promoted ALDOC protein stability and disrupted the ability of ALDOC sensing glucose deficiency, which activated AMPK pathway and increased GBC cell proliferation. ALDOC knockdown significantly inhibited the glucose uptake and glycolysis induced by MUC16c. Our study established important roles of MUC16c promoting GBC cell glycolysis and proliferation and revealed the underlying mechanism of CA-125-related heavy tumor metabolic burden in GBC.
推荐引用方式
GB/T 7714：

Fan Kun,Wang Jiwen,Sun Wentao, et al. MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth [J].EXPERIMENTAL CELL RESEARCH,2020,394(1).
APA：

Fan Kun,Wang Jiwen,Sun Wentao,Shen Sheng,&Liu Han.(2020).MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth .EXPERIMENTAL CELL RESEARCH,394(1).
MLA：

Fan Kun, et al. "MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth" .EXPERIMENTAL CELL RESEARCH 394,1(2020).
入库时间：

2023/12/2 0:00:00
更新时间：

2023/12/2 0:00:00

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