Alterations in bile acid (BA) profiles are closely associated with adverse outcomes in pregnant women and their offspring and may be one potential pathway underlying the related metabolic effects of per- and poly-fluoroalkyl substances (PFAS) exposure. However, evidence of associations between PFAS exposure and BA profiles in pregnant women is scarce. This study examined the associations of individual PFAS and PFAS mixture with BA profiles of pregnant women. We obtained quantitative data on the plasma concentrations of 13 PFAS and 15 BAs in 645 pregnant women from the Jiashan birth cohort. In Bayesian kernel machine regression models, the PFAS mixture was associated with increased plasma CA, TCA, TCDCA, and GLCA levels but with decreased GCA and LCA concentrations. Furthermore, the PFAS mixture was associated with increased concentrations of total BAs and the secondary/primary BA ratio but with decreased conjugated/unconjugated and glycine/taurine-conjugated BA ratios. PFHxS, PFUdA, PFOS, PFNA, and PFDA were the dominant contributors. The results of the linear regression analysis of individual PFAS were generally similar. Our findings provide the first epidemiological evidence for the associations of a PFAS mixture with BA profiles in pregnant women and may provide explanatory insights into the biological pathways underlying the related metabolic effects of PFAS exposure.
[1]Fudan Univ, Shanghai Inst Biomed & Pharmaceut Technol, Shanghai MOST Key Lab Hlth & Dis Genom, NHC Key Lab Reprod Regulat,Sch Publ Hlth, Shanghai 200237, Peoples R China.
[2]Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Clin Res Unit, Shanghai 200092, Peoples R China.
[3]Hubei Prov Ctr Dis Control & Prevent, Hubei Prov Key Lab Appl Toxicol, Natl Reference Lab Dioxin, Wuhan 430079, Peoples R China.
[4]Hosp SIPPR, Shanghai Inst Biomed & Pharmaceut Technol, Shanghai 200032, Peoples R China.
[5]Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China.
(8.0+极速模式)