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Improvement of radiotherapy with an ozone-carried liposome nano- system for synergizing cancer immune checkpoint blockade 期刊论文

编号：

F9E8247BF53E1B9CF7C09A93A677BAD4
作者：

Zheng, Dan^[1,2] Li, Yanchu^[1,2,3] Song, Linlin^[1,2,4,5] Xu, Tianyue^[1,2] Jiang, Xian^[1,2] Yin, Xiaomeng^[6] He, Yinbo^[7] Xu, Jinshun^[4,5] Ma, Xuelei^[6] Chai, Li^[8] Xu, Jie^[9] Hu, Jianping^[10] Mi, Peng^{[11,12,13,14]} Jing, Jing^[1,2] Shi, Hubing^[1,2]
语种：

英文
期刊：

NANO TODAY ISSN：1748-0132 2022 年 47 卷 ; DEC
收录：
关键词：

Ozone delivery Immunotherapy Hypoxia Radiotherapy Tumor microenvironment Nano-system
摘要：

Radiotherapy is a compatible regimen for synergizing immune checkpoint blockade therapy by promoting immunogenic cell death. To improve the efficiency of irradiation-induced neoantigen generation, we de-signed and developed an ozone-carrying liposome perfluorodecalin (PFD) nano-system (O3_PFD@ Liposome) which promoted ozone solubility by 18.4-fold compared to that in water solution. The O3_PFD@ Liposome particle remarkably improved the irradiation-induced hydroxyl radical generation. Evaluation of sub-cellular biodistribution indicated that the nano-system could be efficiently internalized by tumor cells. Upon released inside tumor cells, ozone generated reactive oxygen species under the stimulation of X-ray irradiation. Notably, O3_PFD@Liposome significantly prompted anti-tumor efficacy of radiotherapy without inducing severe adverse effects. The combo regimen with radiotherapy and ozone potently enhanced the infiltration of lymphocytes in the tumor microenvironment by inducing immunogenic cell death, releasing neoantigens, and relieving hypoxia symptom. Consequently, the combination of ozone-fueled irradiation and PD-1 blockade synergistically inhibited the growth of primary and abscopal tumors.(c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
推荐引用方式
GB/T 7714：

Zheng Dan,Li Yanchu,Song Linlin, et al. Improvement of radiotherapy with an ozone-carried liposome nano- system for synergizing cancer immune checkpoint blockade [J].NANO TODAY,2022,47.
APA：

Zheng Dan,Li Yanchu,Song Linlin,Xu Tianyue,&Shi Hubing.(2022).Improvement of radiotherapy with an ozone-carried liposome nano- system for synergizing cancer immune checkpoint blockade .NANO TODAY,47.
MLA：

Zheng Dan, et al. "Improvement of radiotherapy with an ozone-carried liposome nano- system for synergizing cancer immune checkpoint blockade" .NANO TODAY 47(2022).
入库时间：

2023/12/2 0:00:00
更新时间：

2023/12/2 0:00:00

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