Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment.
[1]Fudan Univ, Childrens Hosp, Shanghai 200032, Peoples R China.
[2]Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China.
[3]Zhejiang Univ, Inst Life Sci, Hangzhou 310058, Zhejiang, Peoples R China.
[4]Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R China.
[5]Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA.
[6]Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.
(8.0+极速模式)