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miR-33a suppresses the nuclear translocation of beta-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells 期刊论文

编号：

f395a199-8daf-46ef-b2c8-6455dd11612e
作者：

Liang, Chen^[1];Wang, Zhen^[1];Li, YingYi^[1];Yu, BaoHua(于宝华)^[2]Zhang, Fei^[1];Li, HongYu^[3];
语种：

English
期刊：

TUMOR BIOLOGY ISSN：1010-4283 2015 年 36 卷 12 期 (9395 - 9403) ; DEC
收录：
关键词：

miR-33a beta-Catenin Chemoresistance Pancreatic cancer
摘要：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, partly due to its high level of drug resistance. beta-Catenin is critical for drug resistance in pancreatic cancer, which occurs through multiple mechanisms. Here, we observed that miR-33a targeted the 3'UTR of beta-catenin, inducing apoptosis and inhibiting the growth of human pancreatic cancer cells. Moreover, gemcitabine (GEM) treatment enhanced beta-catenin expression by reducing miR-33a expression in a dose-dependent manner. GEM-resistant MiaPaCa-2(res) cells with a low level of miR-33a expression and high level of beta-catenin expression adopted spindle-shaped morphologies, similar to their morphologies during the epithelial-to-mesenchymal transition (EMT), and their normal morphologies were restored by miR-33a overexpression. Furthermore, miR-33a downregulated beta-catenin nuclear translocation, decreasing the transcription of survivin, cyclin D1, and MDR-1, and the protein expression of slug, vimentin, and N-cadherin, thereby mediating sensitization to GEM. Thus, miR-33a might function as a tumor suppressor to downregulate beta-catenin expression, affecting cell growth, apoptosis, the EMT, and GEM resistance.
推荐引用方式
GB/T 7714：

Liang Chen,Wang Zhen,Li Ying-Yi, et al. miR-33a suppresses the nuclear translocation of beta-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells [J].TUMOR BIOLOGY,2015,36(12):9395-9403.
APA：

Liang Chen,Wang Zhen,Li Ying-Yi,Yu Bao-Hua,&Li Hong-Yu.(2015).miR-33a suppresses the nuclear translocation of beta-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells .TUMOR BIOLOGY,36(12):9395-9403.
MLA：

Liang Chen, et al. "miR-33a suppresses the nuclear translocation of beta-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells" .TUMOR BIOLOGY 36,12(2015):9395-9403.
入库时间：

2019/5/28 20:36:02
更新时间：

2019/5/28 20:36:02

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